Polycomb group proteins and their roles in carcinogenesis
نویسندگان
چکیده
منابع مشابه
ESC, ESCL and their roles in Polycomb Group mechanisms
The Drosophila esc gene is a Polycomb Group (PcG) gene whose product is essential for histone H3 K27 methylation and PcG silencing yet genetic analysis indicated that its product was needed only in the very early embryo. We know now that escl, a close homologue of esc exists in the Drosophila genome. In contrast with earlier studies, we find that both esc and escl are expressed at all stages of...
متن کاملPolycomb group proteins
the market, and this outlay was reflected in the cost of treatment – up to $250 a day. It was agreed that neither the oxazolidinones nor the quinolones, licensed for human use, would be given to animals, but before long the agricultural industry had got its hands on analogues of both, either for growth-enhancement or for therapy. Before long animals around the world were found to be abundantly ...
متن کاملPolycomb Group Proteins in Heart Development
Heart morphogenesis is a complex process that involves orchestration of cardiac cell commitment, differentiation, proliferation, and migration. Much progress has been made toward understanding the molecular mechanisms that regulate these events during normal development. However, the role of chromatin modification for heart development has received comparatively little attention, despite the fa...
متن کاملTranscriptional silencing by polycomb-group proteins.
Polycomb-group (PcG) genes encode chromatin proteins involved in stable and heritable transcriptional silencing. PcG proteins participate in distinct multimeric complexes that deposit, or bind to, specific histone modifications (e.g., H3K27me3 and H2AK119ub1) to prevent gene activation and maintain repressed chromatin domains. PcG proteins are evolutionary conserved and play a role in processes...
متن کاملPolycomb group (PcG) and Trithorax group (TrxG) proteins play evolutionarily conserved roles in the epigenetic regulation of gene
1129 ABSTRACT Trithorax (TRX) antagonizes epigenetic silencing by Polycomb group (PcG) proteins, stimulates enhancer-dependent transcription, and establishes a ‘cellular memory’ of active transcription of PcGregulated genes. The mechanisms underlying these TRX functions remain largely unknown, but are presumed to involve its histone H3K4 methyltransferase activity. We report that the SET domain...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chinese Science Bulletin
سال: 2012
ISSN: 1001-6538,1861-9541
DOI: 10.1007/s11434-012-5225-9